Posted on

How Long Does it Take to Recover from a Shoulder Muscle Tear?

Shoulder muscle tear recovery time

How Long Does It Take to Recover from a Shoulder Muscle Tear?

Shoulder muscle tears and torn tendon injuries can be debilitating injuries that often lead to weeks or even months of recovery time.

Shoulder injuries are most commonly associated with damage to the rotator cuff, a group of muscles which is responsible for stabilizing the shoulder joint and allowing for an array of arm movements.

Given the intricate nature of the shoulder joint, it’s essential to seek immediate medical attention if a shoulder muscle tear is suspected. Proper diagnosis and treatment can significantly reduce shoulder muscle tear recovery time and help athletes return to their sport or individuals who want to regain strength and mobility in their shoulders.

In this blog post, we will discuss and examine the recovery times of shoulder muscle tears and physical therapy strategies for the most complete recovery and efficient return to daily routine and physical activities.

Anatomy of shoulder muscles

Shoulder muscles
Shoulder muscles

The shoulder muscles are a fascinating group of muscles that perform an incredibly complex range of movements, which is why they are often prone to injury. These muscles include the deltoid, rotator cuff, scapula stabilizers, and pectoralis major, all of which work in tandem to facilitate smooth shoulder movement.

 The rotator cuff muscles, for instance, aid in overhead reaching and lifting.

The deltoid muscles of the shoulder play a crucial role in arm movement. They are responsible for helping you lift your arms overhead, move your arm, and push objects away from your body.

Deltoid muscles are located on the uppermost part of the arm, essentially forming a protective sheath around the shoulder joint.

The deltoid can be divided into three distinct sections – anterior, medial, and posterior. While each plays a significant role in shoulder movement and stability, injuries to these muscles can result in a variety of symptoms ranging from mild discomfort to debilitating pain.

Overview of shoulder muscle tears

The shoulder is remarkably versatile, having the greatest range of motion of any joint in the body. Unfortunately, this also means it can be especially prone to injury and other joint issues.

Shoulder muscle tears can vary in severity. Small tears tend to heal on their own, but a complete tear will often require surgery. Shoulder muscle injuries require immediate medical attention to prevent further damage and lessen the probability of future injuries .

For a minor shoulder sprain or mild rotator cuff injuries, a conservative treatment protocol is appropriate and involves physical therapy, rest, and avoiding activities that aggravate the injury. In more severe cases, surgery may be necessary to repair severe sprains or complete tears.

The recovery time for rotator cuff tears largely depends on the extent of the injury and the age and overall health of the individual.

While recovery times vary, it’s important to allow full recovery before returning to activities to prevent re-injury.

Risk factors for shoulder muscle injuries

Repetitive overhead lifting
Repetitive overhead lifting

Shoulder muscle tears are a common injury, especially among individuals who participate in high-impacted sports such as football. Individuals who engage in repetitive heavy lifting or overhead activities, such as weightlifters, baseball pitchers, or swimmers, are also at a higher risk of developing shoulder muscle tears. 

Work-related

Shoulder injuries are not only a problem for athletes; they can also affect those in professions that involve frequent use of the shoulder, such as painting, yard care, and construction. These individuals have an increased likelihood of suffering from shoulder-related ailments.

Aging

Muscles and tendons become less elastic as they age, making them more susceptible to injury (degenerative tear). Likewise, when muscles are not properly warmed up, they become more vulnerable during physical activity. Scar tissue from previous shoulder injuries can also weaken the muscles and make them prone to new tears.

Gender

Women have a higher risk of shoulder injuries due to anatomical differences in their shoulder structure.

Anatomy

Individuals with poor posture that puts excessive stress on the shoulder muscles may eventually experience a tear. Anatomical abnormalities can contribute to shoulder problems and the likelihood of a shoulder muscle tear.

Symptoms and Diagnosis of Shoulder Muscle Tears

Shoulder muscle tears are painful.
Shoulder muscle tears are painful.

As one of the most complex joints in the body, the shoulder is especially susceptible to muscle tears. Shoulder muscle tears are common injuries among professional athletes and laborers who engage in repetitive overhead motions, but they can also occur due to trauma or degenerative conditions.

Symptoms may include severe pain in the affected area, weakness or difficulty moving the arm, and a popping or grinding sensation felt in the shoulder socket.

An orthopedic specialist should be consulted if a muscle tear is suspected. During an examination, the physician will conduct several common orthopedic tests of the injured muscle and surrounding muscles. Additionally, imaging tests such as MRIs or ultrasound are usually used in the diagnostic process.

If additional imaging is needed, an MR arthrogram is usually ordered. This type of MRI is distinct from a regular MRI, as contrast dye is injected into the affected area. The added fluid enhances the images, making it easier to identify tears that may not have been visible before.

Types of shoulder muscle tears

MRI images of torn rotator cuff
MRI images of torn rotator cuff

Most shoulder muscle tears consist of either rotator cuff tears or LHB tears.

Rotator cuff tear

By far the most common of shoulder muscle injuries is a torn rotator cuff. A rotator cuff tear occurs when the one or more of the muscles and tendons that cover the upper arm bone of the affected shoulder (humerus) are damaged or torn.

The rotator cuff is a complex group of four muscles including the praspinatus, infraspinatus, teres minor, and subscapularis. The muscles originate at the scapula (or shoulder blade) and join as tendons to form a dense covering at the top of the humerus. The rotator cuff is responsible for stabilizing the shoulder, allowing for the full range of motion necessary for daily activities, such as lifting and rotating the arm. 

The rotator cuff can become injured through overuse, age, or trauma. Athletes who engage in repetitive overhead motions like throwing or serving are particularly prone to rotator cuff tears. A rotator cuff injury can result in significant shoulder pain, weakness, and loss of motion.

LHB tears

The long head of biceps tendon (LHB) tear is an important part of the shoulder joint. This tendon originates from the shoulder blade and travels through the shoulder joint and attaches to the top of the humerus bone. It functions as a stabilizer of the shoulder joint during arm movement.

A tear of the LHB tendon involves a partial tear or a complete rupture of the tendon fibers that attach the biceps muscle to the shoulder. This can lead to considerable pain, weakness, shoulder instability, and limited range of motion. These tears can occur in a variety of ways, including sudden trauma or overuse, and they can happen to anyone, irrespective of age or activity level. Surgical intervention may be required for severe tears of the LHB tendon.

Treatment options for shoulder muscle tears

Physical therapy
Physical therapy

Shoulder muscle and tendon tears are painful, debilitating injuries that require careful consideration of treatment options for successful recovery. The most common and effective method for treating a milder injury like a shoulder sprain is a combination of conservative treatments like rest, compression, ice therapy, physical therapy, and pain management.

Conservative treatment

Rest is crucial, as it allows a torn rotator cuff to eventually heal and prevents further damage from occurring. Ice pack therapy can help reduce swelling and may help ease pain. Physical therapy strengthening exercises can help to strengthen shoulder muscles and improve range of motion. Pain medication may also be prescribed by a physician for pain relief during the four to six weeks healing period of a shoulder injury.

Other treatment options

In recent years, improvements in treatment options for mild shoulder muscle injuries have become available to medical professionals. Among these are improving posture and shoulder biomechanics, nerve block and steroid injections, and platelet injections. The latest research suggests that improving posture and shoulder biomechanics aid in the healing process, alleviate mild shoulder pain, may help prevent future injury to the rotator cuff, and improve overall shoulder function. Corticosteroid injections work by reducing inflammation and promoting healing. Alternatively, platelet injections can also be utilized to stimulate tissue repair and regeneration.

It is essential to follow the healthcare provider’s instructions and attend all recommended physical therapy sessions to achieve the best possible outcome. With proper care and treatment, most individuals will fully recover from a shoulder muscle injury such as a mild rotator cuff tear and eventually return to playing sports and performing daily activities without complications.

Surgery

Surgery of the shoulder
Surgery of the shoulder

Severe rotator cuff tears often require surgical intervention.

It is important to choose an orthopedic surgeon with expertise in repairing rotator cuff tears, ideally one who has completed a fellowship in sports medicine.

How long does it take to recover from rotator cuff surgery?

The recovery process from shoulder surgery can be a long and grueling process. The length of recovery time after rotator cuff surgery varies based on numerous factors, including the extent of the tear, the type of surgical technique, and the patient’s overall health. Generally, patients can expect to take six to eight weeks, or even several months to recover fully from surgery, with the first few weeks being the most challenging. Pain management, physical therapy, and strict adherence to activity restrictions are all critical components of a successful recovery. However, following these guidelines will lead to a full recovery and restoration of functionality.

Conclusion

A shoulder muscle injury can have significant consequences on future shoulder function and should be taken seriously.

The muscles of the rotator cuff plays a crucial role in shoulder function, as it stabilizes the joint and allows for a range of movements. Therefore, any injury to the rotator cuff can greatly impact the shoulder’s ability to function properly.

It’s important to seek further medical assistance if you experience persistent pain, weakness, or difficulty moving your shoulder, as these symptoms may indicate a rotator cuff tear. Early diagnosis and treatment of sprained shoulder injuries such as rotator cuff tears can prevent further damage and ensure a complete recovery. In some cases, surgery may be necessary to restore full function to the shoulder. Therefore, it’s essential to pay attention to any symptoms that may indicate a shoulder muscle injury and seek medical attention promptly.

Posted on

When does CBD tincture take effect?

CBD Tincture

When Does CBD Tincture Take Effect?

Introduction

As the use of CBD tinctures continue to rise in popularity, it’s important for people to know how much CBD they should take, how long it takes for it to take effect, what consumption methods there are, and what effects they can expect.

This post will explain how long it takes for CBD oil tincture to take effect and what factors can influence this. We’ll provide an overview of the science behind CBD oil absorption as well as tips on how you might be able to increase its effectiveness. Whether you’re just exploring the potential benefits of CBD or are already a regular user, we hope that this article will provide valuable insights into understanding this compound better.

What is CBD Tincture and how does it work?

CBD oil is the main ingredient in a CBD tincture.
CBD oil is the main ingredient in a CBD tincture.

CBD tincture, better known as CBD oil, has gained popularity in health and wellness industries due to its potential benefits on the human body.

A CBD tincture is a liquid extract of hemp derived CBD oil that is mixed with a carrier oil, such as coconut or hemp seed oil. The carrier oil serves as a means of enhancing the bioavailability of the CBD by allowing its absorption into the bloodstream. CBD tinctures contain other beneficial compounds, such as terpenes and flavonoids, which work synergistically with CBD.

CBD oil is typically administered sublingually, or under the tongue, where it is held for 60-90 seconds before swallowing. When consumed this way, the CBD oil is quickly absorbed through the mucous membranes in the mouth, allowing it to enter the bloodstream quickly.

Once in the bloodstream, CBD oil interacts with the endocannabinoid system, which regulates various bodily functions such as mood, appetite, and pain sensation.

CBD capsules

CBD oil can also be taken in capsule form. CBD capsules must travel through the digestive system, leading to a first-pass metabolism which decreases the speed at which CBD takes effect (the bioavailability rate). As such, it may take longer to experience the effects of CBD when taking it in this way.

Unlike other forms of CBD, such as CBD edibles or topicals, CBD oils can be easily customized to fit the user’s desired dose and can provide a more targeted and consistent effect.

Types of CBD oil available on the market and what makes them unique

Some tinctures contain more CBD than others.
Some tinctures contain more CBD than others.

There are many types of CBD oil available on the market, each with its own unique properties.

Some tinctures are formulated to address inflammation, or aid in relaxation, while others focus on promoting energy. Certain tinctures are created with a specific ratio of CBD oil to other cannabinoids, such as THC, to provide targeted pain relief only.

CBD isolate tinctures are the purest form of CBD, containing only that one specific cannabinoid.

When choosing a tincture, it’s important to consider additional factors such as CBD dosage, desired strength, and flavor. 

Full spectrum and broad spectrum

In general, the many types of CBD oil fall under two categories: full spectrum and broad spectrum. Both varieties offer their own unique benefits, but it’s important to understand the differences between the two.

Full-spectrum CBD oil contain all of the naturally occurring cannabinoids, terpenes and flavonoids found in the hemp plant, including THC. This means that they offer a range of benefits and the “entourage effect” in which the cannabinoids work together to produce a stronger effect.

Broad-spectrum CBD oils are similar, but they have undergone additional processing to remove any trace amounts of THC. For those who need to avoid THC for personal or legal reasons, a broad spectrum CBD product is the way to go.

Combination tinctures

Combination CBD tinctures are a relatively new product that combines the benefits of multiple cannabinoids in one convenient package. These tinctures can contain a variety of cannabinoids, such as CBG, CBN, CBDA, and, of course, CBD.

CBG is a non-psychoactive cannabinoid that has been shown to have potential neuroprotective and anti-inflammatory properties. CBN is known for its sedative effects and its potential to aid in sleep. CBDA, the acidic precursor to CBD, has demonstrated anti-inflammatory and anti-nausea properties. CBD, arguably the most well-known cannabinoid, has been shown to have potential benefits for anxiety, pain, and inflammation. 

The unique therapeutic properties of each cannabinoid work together to form a powerful wellness tool. By combining several cannabinoids into one tincture, users can take advantage of this synergistic effect and experience even greater benefits.

With so many different combinations available, consumers can experiment to find an appropriate blend of cannabinoids to suit their individual needs.

Different Methods of Consumption 

Some people add CBD drops to their morning coffee.
Some people add CBD drops to their morning coffee.

There are many different ways to consume CBD. Each of these methods can affect how much and how quickly CBD enters the bloodstream. Different consumption methods may result in varying levels of absorption.

Sublingual administration of CBD oil is a quick and easy way to consume CBD, while adding it to food or drink can make consumption more palatable.

Topical application may provide localized relief for pain or inflammation.

Each method of CBD consumption has its strengths, and the best choice will depend on individual preferences and needs.

Sublingual

CBD oil is usually administered sublingually, meaning under the tongue. It is absorbed through the mucous membrane, allowing fast absorption into the bloodstream. This method simply involves placing a few drops under the tongue and letting it remain there for 30 seconds before swallowing.

When taken sublingually, CBD can bypass the digestive system and enter the bloodstream more quickly, enhancing its potency and efficacy.

Added to food

CBD oil can also be added to food or drinks, such as coffee, tea, or smoothies. This method takes a bit longer for CBD to take effect but can be an excellent option for those who don’t enjoy the taste of CBD.

Topical application

There are also topical applications of CBD tinctures, which involve applying a small amount to the skin or scalp. Topical application of CBD works to provide localized relief for pain or inflammation.

Topical CBD products are often chosen for targeting localized chronic pain in specific areas, as it can be absorbed directly through the surface of the skin. They should be generously applied to maximize absorption of cannabinoids by the skin. Topical CBD effects typically peak after around 90 minutes when this method is used.

The role of carrier oils in speeding up absorption time 

Medium chain triglyceride oil helps deliver the effects of CBD.
MCT oil helps deliver the effects of CBD.

The use of carrier oils in enhancing the absorption time of CBD oil is widely accepted in the scientific and professional community. Carrier oils help dissolve CBD compounds, making them more easily absorbed by the body.

MCT oil

One of the most often used carrier oils used for CBD products is medium chain triglyceride oil, commonly found in coconut oil.

High bioavailability

MCT oil has become the go-to carrier oil for CBD tinctures. The main reason for this is because it is a high-quality, stable oil that can carry CBD effectively. MCT oil is made up of medium-chain fatty acids, which are particularly effective in transporting CBD compounds because it is easily broken down and absorbed by the body.

MCT oil has a high bioavailability which means a greater amount of the CBD is able to reach the bloodstream. This makes MCT oil an ideal carrier oil for CBD, which also needs to be quickly absorbed by the body to have the desired effects.

Additional benefits

Furthermore, MCT oil is odorless, tasteless, and has a long shelf life, making it an ideal carrier for CBD tinctures. Finally, MCT oil has been shown to have therapeutic benefits, such as improving cognitive function and supporting weight loss.

Other carrier oils

While MCT (medium-chain triglyceride) oil is often the carrier oil used in CBD tinctures, it’s not the only option available. In fact, there are several carrier oils on the market that offer unique benefits for absorbing CBD.

For example, hemp seed oil is rich in omega-3 and omega-6 essential fatty acids that can help improve skin health and reduce inflammation.

Grape seed oil is a light and easily absorbed oil that is rich in antioxidants.

Additionally, olive oil contains high levels of oleic acid, which has been shown to improve brain function and reduce the risk of heart disease.

Factors that impact how long it will take for CBD oil to work

Body characteristics can affect how long it takes CBD to work.
Physical characteristics can affect how long it takes CBD to work.

As the use of CBD tinctures becomes more prevalent, understanding the factors that impact the speed of their effects is important.

One key factor is the quality and potency of the tincture itself. High-quality tinctures with a higher concentration of CBD oil tend to be more effective and faster acting.

The method of consumption, whether sublingual, ingestion, or topical, can impact the speed of onset. The sublingual consumption method, where the tincture is placed under the tongue, is generally the fastest method as it allows for absorption directly into the bloodstream. Ingesting CBD oil orally, such as in food or beverages, takes longer to take effect.

Additionally, individual body chemistry and metabolism can also play a role in how long it may take for CBD oil to work.

Other factors that affect the product’s effectiveness include the strength of the tincture, dosage, metabolism and body weight of the user, and the severity of the medical condition

Potential benefits of taking CBD oil regularly 

Fitness-minded individuals may find CBD useful in their muscle recovery regimen.
Fitness-minded individuals may find CBD useful in their muscle recovery regimen.

One of the most significant potential benefits of regular CBD consumption is its ability to reduce inflammation. This presents potential benefits for those dealing with autoimmune disorders and chronic pain conditions, as well as athletes and fitness enthusiasts looking to improve recovery time and prevent injury.

CBD has also shown promising results in addressing symptoms associated with neurological disorders, such as epilepsy, multiple sclerosis, and Parkinson’s disease.

Regular intake of CBD tincture can help promote homeostasis in the body, which refers to the harmonious balance of all bodily functions.

How does this work?

CBD interacts with the body’s endocannabinoid system, which is responsible for regulating functions such as appetite, mood, and even sleep patterns. By modulating the activity of this system, CBD can help bring the body back into balance.

Anti-inflammatory properties

One of the most significant potential benefits of regular CBD consumption is its ability to reduce inflammation and pain, making it a useful tool for managing chronic conditions.

This presents potential benefits for those dealing with autoimmune disorders and chronic pain conditions, as well as athletes and fitness enthusiasts looking to improve recovery time and prevent injury.

Additionally, CBD has shown promising results in addressing symptoms associated with neurological disorders, such as epilepsy, multiple sclerosis, and Parkinson’s disease.

Tips for maximizing the benefits of your CBD tincture experience.

Start with a low dose.
Start with a low dose.

As CBD products continue to gain popularity in the world of wellness, it’s important to understand the best ways to utilize them for optimal benefits. Taking CBD oil daily can provide a range of benefits, but it’s essential to approach it correctly.

First and foremost, start with a low dosage and gradually increase as needed. Consistency is key when it comes to CBD, so setting a daily routine will help you maximize the effects.

Additionally, pay attention to how your body responds to CBD oil and adjust the dosage and time of day taken accordingly. Keeping a daily journal can help track progress and can help you determine how much CBD oil to take.

Take care to choose a high-quality CBD product from a reputable brand to ensure maximum benefits.

Lastly, be sure to consult with a medical professional before incorporating CBD oil into your daily routine.

With careful consideration and guidance, incorporating CBD oil into your daily routine can be a beneficial addition to your wellness journey, and adhering to these tips will help you make the most out of this natural remedy.

Conclusion

Choose a high quality CBD tincture.
Choose a high quality CBD tincture.

In conclusion, the regular use of CBD oil tinctures can be a beneficial addition to one’s wellness journey. CBD oil has been shown to reduce inflammation and pain, as well as help modulate the activity of the endocannabinoid system. However, it’s important to approach using CBD oil responsibly, starting with a low dosage and gradually increasing as needed.

Additionally, it’s a good idea to have realistic expectations of how long it will take for CBD oil to work. Every individual has a unique body chemistry. People have varying diets, lifestyles, and health issues. All of these variables impact how the cannabinoid is absorbed into the body.

Choosing a high-quality product from an established brand is key in maximizing the potential benefits of this natural remedy. For those considering adding CBD oil to their daily routine, consulting with a medical professional is highly recommended. With proper guidance and consistent use, taking CBD oil regularly may potentially offer physical and mental health benefits.  ​  ​

Hemp derived CBD products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to health information from licensed health care practitioners. Please consult your health care professional about potential interactions with prescription medications you may be taking.

Posted on

CBDA vs CBD: Comparing the Two Cannabinoids And Their Benefits

CBDA vs CBD

CBDA vs CBD: Comparing the Two Cannabinoids And Their Benefits

Introduction

You may have heard of CBD, or cannabidiol, non-psychoactive component found in cannabis and hemp plants. Unlike THC, the compound in cannabis that produces a “high” when ingested, it won’t give you a buzz. CBD is used for its calming and anti-inflammatory benefits.

But there is more to Cannabis and hemp than just CBD and THC; other powerful compounds exist within raw cannabis and hemp plants, such as CBDA (cannabidiolic acid), the acid precursor to CBD. This lesser-known cannabinoid also offers a range of potential therapeutic effects.

In this blog post on CBDA vs CBD, we’ll provide an overview of the two cannabinoids and explore the similarities and differences between them along with their potential applications for improving human health.

What are cannabinoids?

Hemp plants
Hemp plants

Cannabinoids are a complex and fascinating group of chemical compounds found in hemp and cannabis plants, with over 100 different types identified to date. These compounds interact with the body’s endocannabinoid system, a complex network of cell receptors and neurotransmitters that helps regulate various physiological functions such as mood, appetite, pain, and sleep.

The most well-known cannabinoid is tetrahydrocannabinol (THC), a psychoactive compound which is responsible for the “high” commonly associated with cannabis use. CBD is another well-known cannabinoid and has been shown to have multiple therapeutic benefits.

Hemp and cannabis are both strains of Cannabis Sativa with different chemical compositions. Cannabis plants are cultivated for recreational and medicinal purposes, while certain strains of hemp are grown specifically for their high levels of CBD and low levels of THC to produce CBD oil and other beneficial cannabinoid-based products.

Cannabinoids have become the focus of considerable scientific research and are being studied for their potential applications in a range of medical conditions, from chronic pain to anxiety and depression. 

What is CBD?

CBD formula
Chemical structure of CBD

Cannabidiol (CBD) is a cannabinoid derived from the cannabis plant. Its molecular structure interacts with the body’s endocannabinoid system, a network of receptors and molecules that help regulate a variety of physiological processes.

Scientists have been especially interested in studying CBD because of its potential medicinal properties. Research has unveiled a wide range of potential health benefits ranging from anti-inflammatory, anti-prolific, analgesic, anxiolytic, and neuroprotective benefits.

CBD does not have psychotropic properties and will not produce the “high” commonly associated with cannabis. CBD oil and other CBD products such as edibles are widely available.

The hemp plant does not directly produce CBD. Instead, it produces CBDA which is then converted to CBD through a process called thermal decarboxylation.

Decarboxylation

When cannabis is smoked, CBDA converts to CBD.
When cannabis is heated, CBDA converts to CBD.

During decarboxylation, a series of chemical reactions occurs that releases a carbon dioxide molecule and removes the carboxyl group- the acidic part- from CBDA, which converts it into CBD.

The combination of heat and time causes the transformation from CBDA to CBD. The process is fairly simple when cannabis is smoked or heated for cooking. However, to make products such as CBD oil and edibles, a more involved and precise process is involved. CBDA is subjected to time-specific, controlled temperatures that are hot enough to cause decarboxylation, but not so hot that the cannabinoid loses any of its beneficial properties.

What is CBDA?

Chemical structure of CBDA
Chemical structure of CBDA

Cannabidiolic acid (CBDA) is a natural compound found in the raw form of the hemp and cannabis plant. It is present in high concentrations in the plant’s tissues, and serves as the precursor of CBD due to its acidic form.

CBDA benefits are similar to those of CBD but there are some differences.  

How does CBDA work?

Despite being a lesser-known compound in the cannabis plant, CBDA shows promise in treating various ailments such as arthritis, cancer, anxiety, and nausea.

One of the ways CBDA interacts with the body is through the endocannabinoid system, specifically the CB1 receptor, which is responsible for regulating mood, appetite, and pain.

CBDA also inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for inflammation and pain in the body. By inhibiting this enzyme, CBDA shows potential therapeutic value in managing various inflammatory conditions.

In addition, CBDA is thought to activate the 5-HT1A serotonin receptor, which may also contribute to its anti-inflammatory and anti-nausea effects.

How is CBDA made?

Chemical structure of CBGA
Chemical structure of CBGA

CBDA is formed from its precursor, cannabigerolic acid (CBGA).

What is CBGA?

Sometimes referred to as the “mother of all cannabinoids”, CBGA is the precursor from which all other cannabinoids are derived. It is the most abundant compound found in the cannabis or hemp plant’s trichomes, which are hair-like glandular structures located in the buds and leaves of the cannabis plant.

Once CBGA interacts with plant enzymes in the trichomes, it forms into three major cannabinoid precursor compounds: Tetrahydrocannabinolic acid (THCA), Cannabichromenic acid (CBCA), and Cannabidiolic acid (CBDA).

Then, when the raw hemp or cannabis is exposed to sunlight and/or heat, a process called decarboxylation takes place and CBDA converts into CBD.

Why isn’t CBDA well known?

Upon initial analyses, CBDA was believed to have little therapeutic value, as acidic forms of cannabinoids were presumed to serve only as precursors to cannabinoids like CBG, CBD, and THC. As a result, the scientific community showed little interest in acidic, unstable cannabis compounds.

In 2008, researchers noticed a striking similarity between the molecular structure of CBDA and existing nonsteroidal anti-inflammatory drugs (NSAIDs). Upon further study, they found that CBDA demonstrated the same COX-2 inhibitory characteristics that make NSAIDs beneficial in managing inflammation, warranting further study of CBDA.

A Difficult research subject

Another reason CBDA’s properties were not known until recently is because CBDA is a problematic substance for scientific study. It is an unstable compound, which makes it difficult to isolate and manipulate.

CBDA rapidly decarboxylates — losing its carboxyl group and becoming CBD — when the plant material is exposed to heat, light, oxygen, or other environmental factors.

Furthermore, CBDA has a very short half-life in the body, meaning that it is quickly broken down and eliminated. All of these factors have presented significant obstacles in studying CBDA.

Stabilized form of CBDA

R. Mechoulam, the cannabis scientist who first synthesized THC and CBD, recently devised a method to overcome the instability of CBDA, allowing for more reliable research into its potential therapeutic benefits.

He and his research team successfully synthesized CBDA into a more stable compound, thus enabling a consistent basis for studying it across various medical applications. This has opened up exciting new avenues for exploring possible CBDA benefits and therapies.

Are CBD and CBDA the same thing?

No, but there is a relationship between the two. Although CBD and CBDA belong to the same family of cannabinoids and offer some similar health benefits, they differ in their chemical structure, properties, and effects on the body.  

CBD vs CBDA

Taking a CBD tincture
Taking a CBD tincture

Similarities between CBDA vs CBD

The main similarity between CBD and CBDA is that they do not have psychotropic properties, which means that consuming them will not cause the user to become high.

CBD and CBDA interact with the endocannabinoid system, a network of receptors and molecules involved in regulating various physiological processes such as pain relief, immune modulation, and mood regulation. CBD and CBDA have been found to have neuroprotective, anti-oxidant, and anti-proliferative properties.

CBDA and CBD inhibit the production of cyclooxygenase-2 (COX-2) enzymes, a key player in the inflammatory response. This makes them potential candidates for treating conditions characterized by inflammation and pain such as arthritis or Crohn’s disease.

So what is the difference between CBDA vs CBD?

The main difference between CBDA and CBD is that one is the precursor of the other, meaning that CBDA converts to CBD through the decarboxylation process.

CBD and CBDA exhibit some distinct differences in how they interact with the human body.

Although both CBDA and CBD have been found to inhibit COX-2 enzymes from producing inflammatory compounds, some studies found that CBDA boosts activity in the endocannabinoid system without binding to cannabinoid receptors at all.

Greater bioavailability

CBDA has a higher degree of bioavailability than CBD, meaning it is more easily absorbed and used by the body.

Its higher bioavailability is due to its unique chemical structure that allows it to easily pass through cell membranes and interact more effectively with the endocannabinoid system. 

How to take CBD and CBDA

Raw hemp smoothie
Raw hemp smoothie

CBD and CBDA products can be found in capsule, tincture, topical creams, and edible forms.

High-quality CBD oils are easy to find, but finding quality CBDA oils can be difficult to source, as acidic cannabinoids are more challenging to extract and stabilize. Those currently available come in several forms: CBDA Isolate, Broad Spectrum, and Full Spectrum.

A key factor in finding quality CBD and CBDA products is understanding where and how the oil was sourced. It is recommended to choose brands that use organic hemp, do not use artificial additives, have a third-party testing system in place, and provide clear indication of the dosages.

Some health conscious cannabis users are consuming CBDA by juicing raw hemp and adding it to smoothies to fully access its therapeutic properties. Unfortunately, CBDA products like raw cannabis juice are not widely available yet.

CBD and CBDA Benefits

CBDA and CBD show therapeutic potential for a range of health conditions.
CBDA and CBD have anti-inflammatory properties.

Inflammation

Inflammation is a complex process that involves many different biological pathways. Among the cannabinoids, CBD and CBDA are some of the most promising for their potential to relieve chronic inflammatory conditions such as arthritis and Crohn’s disease.

A recent study comparing the anti-inflammatory effects of CBD and CBDA found that they each reduce inflammation through unique mechanisms.

CBD and CBDA inhibited the activity of several key pro-inflammatory cytokines, but CBDA went a step further by inhibiting the production of nitric oxide, a potent pro-inflammatory molecule.

Additional studies suggest that the anti-inflammatory effects of CBDA are as effective as nonsteroidal anti-inflammatory drugs.

Neuroprotection

The brain has many CB1 receptors.
Numerous CB1 receptors are located in the brain.

Research indicates that the anti-inflammatory properties of CBD and CBDA seem to reduce neurological damage caused by inflammation, toxins, or injury, and may be useful in preventing or treating various neurological conditions.

The cannabinoids work by interacting with CB1 and CB2 receptors in the brain and regulating neurotransmitter levels to alleviate inflammation, oxidative stress, and excitotoxicity in the brain, all of which are linked to neurodegeneration.

These findings provide a scientific basis for the use of CBD and CBDA as neuroprotective agents, opening up new avenues for the development of treatments for various neurological disorders like Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis.

Cancer

Scientists are studying the antiproliferative and proapoptotic properties of CBDA and CBD.
Scientists are studying the antiproliferative and proapoptotic properties of CBDA and CBD.

In studies, CBD and CBDA have exhibited antiproliferative and proapoptotic activities- meaning they prevented cancer cells’ growth and spread- on several types of cancer cells, including breast, lung, colon, and prostate cancers.

Scientists have also found that CBDA induces apoptosis, or cell death, in cancer cells while leaving healthy cells untouched. These findings suggest that CBDA has potential as a more targeted and less harmful alternative to traditional cancer treatments such as chemotherapy.

Nausea

The anti-emetic effects of CBD and CBDA have drawn interest interest from the scientific world due to their ability to interact with serotonin receptors in the brain, which play a crucial role in regulating nausea and vomiting. In studies, consumption of CBDA or CBD produced little to none of the side effects of traditional anti-emetic medications.

Additionally, CBD and CBDA appears to reduce the activity of certain neurotransmitters in the brain, further contributing to their anti-emetic effects.

A Canadian study found that CBDA was significantly more effective than CBD in binding to serotonin receptors linked to anti-nausea and anti-anxiety effects when given along with low doses of the traditional anti-nausea drug ondansetron for chemotherapy patients. This finding was measured as being one hundred times more powerful.

Epilepsy

The anti-inflammatory and neuroprotective effects of CBD and CBDA make them potentially valuable treatment options for epilepsy, a debilitating neurological disorder affecting millions worldwide. Although both cannabinoids possess strong anticonvulsant properties, they each work differently.

CBDA‘s anticonvulsant properties are attributed to its unique mode of action on the endocannabinoid system. CBDA interacts with the CB1 and CB2 receptors, modulating the GABAergic and glutamatergic neurotransmitter systems, thereby reducing seizure activity. In several studies involving animal models, CBDA reduced the frequency and severity of epileptic seizures.

The underlying mechanisms of how CBD works to reduce seizures are not yet fully understood. Scientists think that it interacts with receptors in the brain that play a role in regulating seizures.

New research by scientists at NYU Grossman School of Medicine suggests that CBD prevents seizures from occurring by reducing hyperexcitability in neurons and inhibiting the synaptic effects of lysophosphatidylinositol, an endogenous membrane phospholipid.

Mood disorders

CBDA and CBD may have anxiolytic properties.
CBDA and CBD are being studied for their potential anxiolytic properties.

Anxiety is a common mental health issue that affects many people around the world. Studies suggest that both CBD and CBDA may help reduce symptoms of generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder.

CBD, which is known for its calming effect, interacts with CB1 and CB2 receptors in the brain to affect serotonin levels, thus stabilizing mood and relieving anxiety. On the other hand, CBDA seems to work in a slightly different manner to regulate serotonin by interacting with the 5-HT receptors located throughout the body.

Serotonin, a neurotransmitter involved in regulating moods, is greatly affected by the activity of the 5-HT1A receptor. CBDA has a greater affinity to the 5-HT1A receptor than CBD, suggesting it may have more potent anxiolytic effects.

Depression

CBD and CBDA are being studied for their potential as therapeutic options for depression. It appears that CBDA works similarly to antidepressant drugs but without some of the side effects. Furthermore, CBDA may be effective at doses far lower than those used for CBD— ten to 100 times less.  This could make it a more cost-effective treatment option.

CBDA vs CBD: summary

Overall, CBDA and CBD offer diverse health benefits that may be of use to a wide variety of individuals. The data regarding the potential benefits of CBDA is only beginning to emerge; however, it seems to hold promise in treating many ailments and diseases. Although further research is needed, it appears that these CBD and CBDA have the potential to improve overall wellness.

Some caution should be used when exploring the use of cannabinoids since there may be legal, safety and overall health implications.

CBDA and CBD oils may not be the perfect fit for everyone. While these oils are generally safe and well-tolerated by most individuals, it is important to be aware of potential interactions with other medications. This is why it is important to consult with a medical professional before incorporating CBD or CBDA into a daily supplement routine. A qualified healthcare provider can provide guidance on recommended dosage accounts and assess how CBD or CBDA interacts with other prescription medications currently being taken.

For further reading

Campos AC, Fogaça MV, Sonego AB, Guimarães FS. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacological Research. 2016 Oct;112:119-127. doi: 10.1016/j.phrs.2016.01.033. Epub 2016 Feb 1. PMID: 26845349.

Formato, Marialuisa et al. “(‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research.” Molecules (Basel, Switzerland) vol. 25,11 2638. 5 Jun. 2020, doi:10.3390/molecules25112638 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321064/#B40-molecules-25-02638

Gusho, Charles A, and Tannor Court. “Cannabidiol: A Brief Review of Its Therapeutic and Pharmacologic Efficacy in the Management of Joint Disease.” Cureus vol. 12,3 e7375. 23 Mar. 2020, doi:10.7759/cureus.7375 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176325/

Hirao-Suzuki M et al. 2020. “Cannabidiolic Acid Dampens the Expression of Cyclooxygenase-2 in MDA-MB-231 Breast Cancer Cells: Possible Implication of the Peroxisome Proliferator-activated Receptor β/δ Abrogation.” Journal of Toxicology Science, 45(4):227-236. doi: 10.2131/jts.45.227. PMID: 32238697. https://pubmed.ncbi.nlm.nih.gov/32238697/

Kim, Juyong et al. 2023. “The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model.” International Journal of Molecular Sciences vol. 24,7 6827. 6, doi:10.3390/ijms24076827 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095267/

Kleinhenz, M. D. et al. 2022. “Short Term Feeding of Industrial Hemp With a High Cannabidiolic Acid (CBDA) Content Increases Lying Behavior and Reduces Biomarkers of Stress and Inflammation in Holstein Steers.” Scientific Reports vol. 12,1 3683, doi:10.1038/s41598-022-07795-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901777/

Maroon J, Bost J. Review of the neurological benefits of phytocannabinoids. Surgical Neurology International 2018 Apr 26;9:91. doi: 10.4103/sni.sni_45_18. PMID: 29770251; PMCID: PMC5938896. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938896/pdf/SNI-9-91.pdf

Rock, E M, & Parker, L. A. “Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats.” British Journal of Pharmacology vol. 169,3 (2013): 685-92. doi:10.1111/bph.12162 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682714/